Inhibiting Sec61

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The Sec61 translocon is a highly conserved transmembrane channel complex in the endoplasmic reticulum (ER) membrane that is required for the biogenesis of most secreted and membrane proteins, facilitating the translocation or membrane integration of nascent polypeptides.

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doi: https://doi.org/10.1038/d41573-023-00086-w

Itskanov, S. et al. A common mechanism of Sec61 translocon inhibition by small molecules. Nat. Chem. Biol. https://doi.org/10.1038/s41589-023-01337-y (2023)

Rehan, S. et al. Signal peptide mimicry primes Sec61 for client-selective inhibition. Nat. Chem. Biol. https://doi.org/10.1038/s41589-023-01326-1 (2023)

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