Injection Grade Human Cathelicidin Ropocamptide Antibacterial Protein Anti-Inflammatory Peptides Ll37 Ll-37 USA Warehouse

Basic Info

Model NO.	LL-37
Powder	Yes
Customized	Customized
Certification	HSE, ISO 9001, USP
Suitable for	Elderly, Adult
State	Solid
Purity	>98%
Product Name	Ll-37
Chemical Name	Cathelicidin
CAS No	154947-66-7
Appearance	White Lyophilized Powder
Grade Standard	Injection Grade
Application	Anti-Inflammatory and Antimicrobial
UK Warehouse	Shipping Within 48hrs
Shipping	FedEx, DHL, EMS, TNT, 4px, Royal Postal, Aramex
Payment	Debit Card, Btc, Wu, Moneygram, T/T
Certificate	GMP, HPLC, COA, MSDS
Shelf Life	24month
Storage	Refrigeration Keep Dry and Away From Light.
Transport Package	10vials/Kit
Specification	5mg/Vials
Trademark	Niche
Origin	China
HS Code	2935900098
Production Capacity	100000vials/Month

Product Description

Injection grade Human Cathelicidin Ropocamptide Antibacterial Protein Anti-inflammatory peptides LL37 LL-37 USA warehouse Product Description

Detailed Product Information

Product Name: LL-37
CAS No.: 154947-66-7
Molecular Formula:C205H341N61O52
Molecular Weight:4492.3g/mol
Purity : 98% HPLC
Sequence:H-LEU-LEU-GLY-ASP-PHE-PHE-ARG-LYS-SER-LYS-GLU-LYS-ILE-GLY-LYS-GLU-PHE-LYS-ARG-ILE-VAL-GLN-ARG-ILE-LYS-OH H-ASP-PHE-LEU-ARG-ASN-LEU-VAL-PRO-ARG-THR-GLU-SER-OH
Appearance: White Lyophilized Powder
Typical use: Anti-inflammatory AntibacterialShelf Life :12month
Storage: Refrigeration keep dry and away from light.
Description:

What is LL-37 Peptide?
LL-37 is the only known human Cathelicidin is a big protein family where the members exhibit diverse functions. These peptides, essentially produced by macrophages and polymorphonuclear leukocytes (both types of white blood cells), have bactericidal action. They have been found to have shown other substantial effects as well. The entire group is often referred to as antimicrobial peptides (AMPs). LL-37 in particular has been found to play significant roles in autoimmune disease, cancer, and wound healing.

LL-37 AND INFLAMMATORY DISEASES
LL-37, although essentially known to be an antimicrobial peptide, is also involved in different inflammatory diseases such as lupus, rheumatoid arthritis, psoriasis and atherosclerosis. LL-37 plays diverse immune system modulating behaviors based on the type of cells involved and the local inflammatory environment. It has been observed to:
- reduce apoptotic death of keratinocytes,
- improve IFN-alpha synthesis,
- suppress signaling through toll-like receptor 4 (TLR4),
- modify chemotaxis of neutrophils and eosinophils,
- trigger IL-18 production, and
- reduce levels of atherosclerotic plaques.
Interestingly, CAP-18 stimulates the immune system in a different manner depending on the trigger. Cell culture studies have highlighted the importance of inflammatory environment in determining the immune response to LL-37. T-cells, improve their inflammatory actions because of LL-37 when they are not activated but minimize the inflammatory action when already activated. The peptide appears to mediate homeostasis of immunological response thus controlling it from being hyperactive when the body is suffering from infection. It helps to control levels of inflammation in autoimmune diseases. There is a strong correlation between the levels of the peptide and the extent of the disease. Initially, CAP-18 was thought to promote autoimmune disorder but recent results have shown it helps to abate the damage. High levels of the peptide thus help to check further increase inflammation.

BLOOD VESSEL GROWTH
The peptide helps to produce prostaglandin E2 (PGE2) in endothelial cells. In endothelial cells, PGE2 promotes the development of blood vessels via a process called angiogenesis. It is crucial to regulate angiogenesis as it impacts cancer development, stroke outcomes, heart disease, wound healing, and more. LL-37 helps to study angiogenesis in-depth to promote it in cardiac disease and discourage cancer milieu.

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Certifications

Appearance	Blue powder.
Purity	99%min
Single Impurity (HPLC)	1.0%max
Amino Acid Composition	±10% of theoretical
Peptide Content (N%)	≥80.0%
Water Content(Karl Fischer)	≤6.0%
Acetate Content (HPIC)	≤15.0%
MS(ESI)	Consistent
Mass Balance	95.0~105.0%
Specific Rotation (20/D)	-65.0~-75.0°(c=0.5 1%HAc)
Solubility	H 2 O:40 mg / mL
Storage condition	-20ºC
Shelf life	2 years

Packing:

• Delivery Time: Around 3-5 workdays after your payment.
• Package: In fiber-drums with two-plastic bags inside.
• Net Weight: 25kgs/Drum / Gross Weight: 28kgs/Drum
• Drum Size & Volume: I.D.42cm × H52cm, 0.08 m³/ Drum
• Storage: Stored in dry and cool place, keep away from strong light and heat.
• Shelf Life: Two years when properly stored.

Shipping:

• 1, DHL Express, FEDEX and EMS for quantity less than 50KG, usually called as DDU service;
• 2, Sea shipping for quantity over 500KG; and air shipping is available for 50KG above;
• 3, For high value products, please select air shipping and DHL express for safe;
• 4, Please confirm if you can make the clearance when goods reach your customs before placing an order, for buyers from Mexico, Turkey, Italy, Romania,Russia, and other remote area.

Q&A
Q1: How to confirm the Product Quality before placing orders?
A: By sending you our available samples.
Or if you have special requirement on the goods, we can prepare samples according to your requirement for your confirmation.

Q2: Can you supply free samples?
A: Yes, we can provide some free sample, but the shipping cost should be on the customers' account. You can either pay the shipping cost or arrange a courier to collect the samples.

Q3: What's the MOQ?
A: For the high value product, our MOQ starts from 1g and generally starts from 10g.
For other low value product, our MOQ starts from 100g and 1kg.

Q4: How to place order and make payment?
A: You can send our your Purchase order(if your company has), or just send a simple confirmation by email or by TradeManager, and we will send you Proforma Invoice with our bank details for your confirmation, then you can make payment accordingly.

Q5: How do you treat quality complaint?
A: All our products are strictly tested by our QC, and confirmed by QA; unqualified material will not be released to customer.
In case any quality problem is confirmed to be caused by us, we will replace the goods or refund your payment immediately.
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